The history of viticulture in the Neszmély Wine Region dates back to the Roman era. During the one and a half centuries of Ottoman occupation, the vineyards were neglected and became overgrown with land. However, by the 1700s, production and winemaking had once again flourished, with significant quantities of wine being exported to Czech, Polish, German, French, and English markets with the help of merchants from Komárom, Győr, and Bratislava.

At that time, the Meleges-hegy and Korma areas in Neszmély were already well-known as prime grape-growing locations.

In 1832-33, Ferenc Schams created the first overview of the wine regions, with Neszmély listed as part of Komárom County. According to the 1893 XXIII Wine Act, the Neszmély Wine Region extended across the territories of Esztergom, Fejér, Győr, and Veszprém counties.

In 1875, the appearance of phylloxera (Dactylosphaira vitifolii) caused significant damage here as well. The pest did not thrive in soils with high quartz content, so sandier areas were planted instead. Another possible solution to combat phylloxera was the establishment of vineyards with wild American species, which were grafted with European cuttings, creating resistant hybrid vineyards. Before the phylloxera epidemic, grape varieties such as Fehér Gohér, Sárfehér, Olaszrizling, Ezerjó, Oportó, and Merlot were common.

It was once believed that Neszmély wines took 4-5 years to mature, but over time, the older the wine, the more it would develop a pure golden color.

In 1959, due to quality and production issues, the region lost its wine-growing status, which was only restored in 1977. Instead of low head training, high vine training and wide-row planting became the standard. At the same time, the varietal structure changed. In the Ászár region, Ezerjó was pushed out, and varieties such as Chardonnay, Olaszrizling, Királyleányka, and Rizlingszilváni took its place.

Today, the wine region spans approximately 1,200 hectares. The most important varieties include Chardonnay, Sauvignon Blanc, Szürkebarát, and Királyleányka. Among the red wine grapes, Pinot Noir and Kékfrankos are the most significant.